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4-Methoxy-2-aminobenzothiazole
- Name: 4-Methoxy-2-aminobenzothiazole
- CAS: 5464-79-9
- Purity: 99%
Details
Offer Chemical Raw Material 4-Methoxy-2-aminobenzothiazole 5464-79-9 In Stock
- Molecular Formula: C8H8N2OS
- Molecular Weight: 180.23
- Appearance/Colour: Beige crystalline powder
- Melting Point: 153-155 °C(lit.)
- Refractive Index: 1.5690 (estimate)
- Boiling Point: 347.455 °C at 760 mmHg
- PKA: 4.09±0.10(Predicted)
- Flash Point: 163.935 °C
- PSA： 76.38000
- Density: 1.359 g/cm3
- LogP: 2.46830
4-Methoxy-2-aminobenzothiazole(Cas 5464-79-9) Usage
|
Air & Water Reactions |
Insoluble in water. |
|
Reactivity Profile |
An amine, organosulfide. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. |
|
Health Hazard |
ACUTE/CHRONIC HAZARDS: When heated to decomposition 4-Methoxy-2-aminobenzothiazole emits very toxic fumes of NOx and SOx. |
|
Fire Hazard |
Flash point data for 4-Methoxy-2-aminobenzothiazole are not available. 4-Methoxy-2-aminobenzothiazole is probably combustible. |
|
Biochem/physiol Actions |
2-Amino-4-methoxybenzothiazole on condensation reaction with 4-acetamidobenzaldehyde affords tridentate Schiff bases. It reacts with 2,4,6-trichloro 1,3,5-triazine to give 2-(4-methoxybenzothiazol-2′-ylamino)-4-(phenylthioureido)-6-(substitutedthioureido)-1,3,5-triazines. |
|
General Description |
Beige chunky solid. |
InChI:InChI=1/C8H8N2OS/c1-11-5-3-2-4-6-7(5)10-8(9)12-6/h2-4H,1H3,(H2,9,10)
5464-79-9 Relevant articles
Scalable synthesis and antibacterial evaluation of 2-(3-(N-(substituted phenyl)sulfamoyl)ureido)benzothiazoles
Cheraiet, Zinelaabidine,Meliani, Saida,Nessaib, Mounir,Hessainia, Sihem,Boukhari, Abbas,Djahoudi, Abdelghani,Regainia, Zine
, (2019/08/12)
A new series of 2-(3-(N-(substituted phe...
Novel Triapine Derivative Induces Copper-Dependent Cell Death in Hematopoietic Cancers
Chen, Ge,Niu, Chunyi,Yi, Jianhua,Sun, Lin,Cao, Hengyi,Fang, Yanjia,Jin, Taijie,Li, Ying,Lou, Chunli,Kang, Jingwu,Wei, Wanguo,Zhu, Jidong
, (2019/04/01)
Triapine, an iron chelator that inhibits...
Novel Triapine Derivative Induces Copper-Dependent Cell Death in Hematopoietic Cancers
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, p. 3107 - 3121 (2019/04/01)
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SN-Donor methylthioanilines and copper(II) complexes: Synthesis, spectral properties, and in vitro antimicrobial activity
Olalekan, Temitope E.,Ogunlaja, Adeniyi S.,Watkins, Gareth M.
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Methylthioanilines, a series of sulfur-n...
5464-79-9 Process route
-
-
1516-37-6
1-(2-methoxyphenyl)thiourea
-
-
5464-79-9
4-methoxy-1,3-benzothiazol-2-amine
| Conditions | Yield |
|---|---|
|
With
bromine; acetic acid; lithium bromide;
at 40 ℃;
for 17h;
|
94.08%
|
|
1-(2-methoxyphenyl)thiourea;
With
bromine;
In
chloroform;
at 0 - 5 ℃;
Reflux;
With
ammonia;
In
water;
|
70%
|
|
With
chloroform; bromine;
|
|
|
With
sulfuryl dichloride; chlorobenzene;
|
|
|
With
bromine;
In
chloroform;
for 4h;
Heating;
|
|
|
With
bromine;
In
chloroform;
|
|
|
With
bromine;
In
chloroform;
at 10 ℃;
for 1h;
Reflux;
|
|
|
1-(2-methoxyphenyl)thiourea;
With
bromine;
In
tetrachloromethane;
With
ammonia;
In
ethanol;
|
|
|
With
bromine;
Reflux;
|
|
|
With
bromine; acetic acid; lithium bromide;
at 40 ℃;
|
|
|
1-(2-methoxyphenyl)thiourea;
With
bromine;
at 0 ℃;
With
ammonia;
|
-
-
90-04-0
2-methoxy-phenylamine
-
-
ammonium thiocyanate
-
-
5464-79-9
4-methoxy-1,3-benzothiazol-2-amine
| Conditions | Yield |
|---|---|
|
2-methoxy-phenylamine; ammonium thiocyanate;
With
acetic acid;
at 10 ℃;
With
bromine;
at 10 - 20 ℃;
for 4h;
|
74%
|
|
Multistep reaction;
(i), (ii) Br2;
|
|
|
With
bromine; acetic acid;
at 0 - 20 ℃;
|
5464-79-9 Upstream products
-
1516-37-6
1-(2-methoxyphenyl)thiourea
-
90-04-0
2-methoxy-phenylamine
-
67-66-3
chloroform
-
7726-95-6
bromine
5464-79-9 Downstream products
-
7471-03-6
2-amino-4-hydroxybenzothiazole
-
63205-32-3
3-benzyl-2-(4-methoxy-benzothiazol-2-ylimino)-5-methyl-thiazolidin-4-one
-
35412-20-5
N -(4-methoxy-benzothiazol-2-yl)-benzamide
-
68501-20-2
6-methoxy-4-phenyl-benzo[4,5]thiazolo[3,2-a ]pyrimidin-2-one
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