2-CHLORO-5-(FLUOROSULFONYL)BENZOIC ACID

  • Name: 2-CHLORO-5-(FLUOROSULFONYL)BENZOIC ACID
  • CAS: 21346-66-7
  • Purity: 99%
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Details

Reputable factory supply 2-CHLORO-5-(FLUOROSULFONYL)BENZOIC ACID 21346-66-7 in bulk at low price

  • Molecular Formula: C7H4ClFO4S
  • Molecular Weight: 238.624
  • Vapor Pressure: 3.97E-06mmHg at 25°C 
  • Melting Point: 148-150oC(lit.) 
  • Boiling Point: 370°C at 760 mmHg 
  • PKA: 2.05±0.25(Predicted) 
  • Flash Point: 177.6°C 
  • PSA： 79.82000 
  • Density: 1.649g/cm3 
  • LogP: 2.77720 

2-CHLORO-5-(FLUOROSULFONYL)BENZOIC ACID(Cas 21346-66-7) Usage

InChI:InChI=1/C7H4ClFO4S/c8-6-2-1-4(14(9,12)13)3-5(6)7(10)11/h1-3H,(H,10,11)

21346-66-7 Relevant articles

Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate

Grimster, Neil P.,Connelly, Stephen,Baranczak, Aleksandra,Dong, Jiajia,Krasnova, Larissa B.,Sharpless, K. Barry,Powers, Evan T.,Wilson, Ian A.,Kelly, Jeffery W.

supporting information, p. 5656 - 5668 (2013/06/04)

Molecules that bind selectively to a giv...

21346-66-7 Process route

2-chloro-5-(chlorosulfonyl)benzoic acid
137-64-4

2-chloro-5-(chlorosulfonyl)benzoic acid

2-chloro-5-(fluorosulfonyl)benzoic acid
21346-66-7

2-chloro-5-(fluorosulfonyl)benzoic acid

Conditions
Conditions Yield
With potassium hydrogen bifluoride; In 1,4-dioxane; water; at 20 ℃; for 0.5h; Inert atmosphere;
98%
ortho-chlorobenzoic acid
118-91-2

ortho-chlorobenzoic acid

2-chloro-5-(fluorosulfonyl)benzoic acid
21346-66-7

2-chloro-5-(fluorosulfonyl)benzoic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: chlorosulfonic acid / 1 h / 120 °C / Inert atmosphere
2: potassium hydrogen bifluoride / 1,4-dioxane; water / 0.5 h / 20 °C / Inert atmosphere
With chlorosulfonic acid; potassium hydrogen bifluoride; In 1,4-dioxane; water;

21346-66-7 Upstream products

  • 137-64-4
    137-64-4

    2-chloro-5-(chlorosulfonyl)benzoic acid

  • 118-91-2
    118-91-2

    ortho-chlorobenzoic acid

21346-66-7 Downstream products

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    2-chloro-5-(methylsulfamoyl)benzoic acid

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