2-(4-fluorophenyl)propionic acid
- Name: 2-(4-fluorophenyl)propionic acid
- CAS: 75908-73-5
- Purity: 99%
Details
Buy high quality and low price 2-(4-fluorophenyl)propionic acid 75908-73-5 now
- Molecular Formula: C9H9FO2
- Molecular Weight: 168.168
- Vapor Pressure: 0.00688mmHg at 25°C
- Refractive Index: 1.519
- Boiling Point: 258.8 °C at 760 mmHg
- Flash Point: 110.3 °C
- PSA： 37.30000
- Density: 1.215 g/cm3
- LogP: 2.01380
2-(4-fluorophenyl)propionic acid(Cas 75908-73-5) Usage
|
General Description |
2-(4-fluorophenyl)propionic acid, also known as flurbiprofen, is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to treat pain, inflammation, and stiffness caused by conditions such as arthritis. It works by inhibiting the production of certain chemicals in the body that cause inflammation and pain. Flurbiprofen is available in various forms including tablets, capsules, and topical solutions. Like other NSAIDs, it may cause side effects such as stomach upset, dizziness, and headache, and it should be used with caution in individuals with certain medical conditions such as heart disease and kidney problems. Long-term use of flurbiprofen may also increase the risk of serious cardiovascular events such as heart attack and stroke. |
InChI:InChI=1/C9H9FO2/c1-6(9(11)12)7-2-4-8(10)5-3-7/h2-6H,1H3,(H,11,12)
75908-73-5 Relevant articles
2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonists
Ann, Jihyae,Bahrenberg, Gregor,Blumberg, Peter M.,Choi, Sun,Christoph, Thomas,Do, Nayeon,Frank-Foltyn, Robert,Ha, Heejin,Jeong, Jin Ju,Kang, Jin Mi,Kim, Changhoon,Kwon, Sun Ok,Lee, Jeewoo,Lee, Sunho,Lesch, Bernhard,Stockhausen, Hannelore,Vu, Thi Ngoc Lan,Yoon, Sanghee
, (2021/07/28)
A series consisting of 117 2-(halogenate...
Photocatalytic Carboxylation of Phenyl Halides with CO2 by Metal-Organic Frameworks Materials
Han, Jianyu,Qiu, Xueying,Su, Lina,Tang, Zhiyong,Zhang, Yin
, p. 312 - 316 (2021/01/04)
In this work, important commercial pharm...
Suppressing carboxylate nucleophilicity with inorganic salts enables selective electrocarboxylation without sacrificial anodes
Corbin, Nathan,Lazouski, Nikifar,Manthiram, Karthish,Steinberg, Katherine,Yang, Deng-Tao
, p. 12365 - 12376 (2021/10/08)
Although electrocarboxylation reactions ...
Functionalization of α-C(sp3)?H Bonds in Amides Using Radical Translocating Arylating Groups
Radhoff, Niklas,Studer, Armido
supporting information, p. 3561 - 3565 (2021/01/04)
α-C?H arylation of N-alkylamides using 2...
75908-73-5 Process route
-
-
50415-71-9
methyl 2-(4-fluorophenyl)propanoate
-
-
75908-73-5
(+/-)-2-(4-flurophenyl)propanoic acid
| Conditions | Yield |
|---|---|
|
With
potassium hydroxide;
In
ethanol; water;
at 0 ℃;
for 8h;
|
100%
|
|
methyl 2-(4-fluorophenyl)propanoate;
With
methanol; potassium hydroxide;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
With
hydrogenchloride;
In
water;
|
|
|
With
water; potassium hydroxide;
In
ethanol;
at 0 ℃;
for 4h;
|
|
|
With
potassium hydroxide;
In
ethanol; water;
at 0 ℃;
for 4h;
|
|
|
With
water; potassium hydroxide;
In
ethanol;
at 0 ℃;
for 4h;
|
|
|
With
potassium hydroxide;
In
ethanol; water;
at 0 ℃;
for 4h;
|
15.64 g
|
|
With
potassium hydroxide;
In
ethanol; water;
at 0 ℃;
for 4h;
|
|
|
With
water; potassium hydroxide;
In
ethanol;
at 0 ℃;
for 4h;
|
15.64 g
|
|
With
water; potassium hydroxide;
In
ethanol;
at 0 ℃;
for 4h;
|
-
-
405-99-2
para-fluorostyrene
-
-
201230-82-2
carbon monoxide
-
-
459-31-4
3-(4-fluorophenyl)propanoic acid
-
-
75908-73-5
(+/-)-2-(4-flurophenyl)propanoic acid
| Conditions | Yield |
|---|---|
|
With
iron(III) trifluoromethanesulfonate; water; palladium diacetate; triphenylphosphine;
In
1,4-dioxane;
at 120 ℃;
for 10h;
under 7500.75 Torr;
Overall yield = 85 %; regioselective reaction;
Sealed tube;
Inert atmosphere;
Autoclave;
|
|
|
With
Pd(2+)*2Cl(1-)*2C24H39P; water; iron(II) chloride;
In
dimethyl sulfoxide;
at 80 ℃;
for 20h;
under 7500.75 Torr;
Overall yield = 85 percentChromat.;
Sealed tube;
|
75908-73-5 Upstream products
-
107727-68-4
Sodium; 2-(4-fluoro-phenyl)-1-hydroxy-propane-1-sulfonate
-
917-64-6
methyl magnesium iodide
-
706-08-1
trans-1-(4-fluorophenyl)-2-nitro-ethene
-
50415-71-9
methyl 2-(4-fluorophenyl)propanoate
75908-73-5 Downstream products
-
191726-04-2
2-(4-fluorophenyl)propanoyl chloride
-
55023-61-5
2-(4-fluorophenyl)propan-1-ol
-
762298-56-6
2-(4-FLUOROPHENYL)-N-(3-{4-[3-(ISOBUTYRYLAMINO)PHENYL]-1-PIPERIDINYL}PROPYL)PROPANAMIDE
-
762298-60-2
N-(3-{4-[4-FLUORO-3-(ISOBUTYRYLAMINO)PHENYL]-1-PIPERIDINYL}PROPYL)-2-(4-FLUOROPHENYL)PROPANAMIDE
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